Experimental demonstration of TM lateral leakage in a standard SOI photonics platform

We provide an experimental demonstration of the width dependent losses of the fundamental TM guided mode in fabricated silicon-on-insulator shallow etched ridge waveguides

A broadband metasurface Luneburg lens for microwave surface waves

This is the author accepted manuscript. The final version is available from AIP Publishing via the DOI in this recordA broadband planar microwave Luneburg lens made of a three-layer metasurface with hexagonal symmetry is presented. This metasurface supports a transverse-electric mode confined to the surface that presents very low dispersion and a stable mode index across a broad frequency band. This enables the lens to operate in the range of frequencies between 8 GHz and 19 GHz. The lens was manufactured using a lithographic technique with three 25 μm copper-coated Mylar sheets. The resulting device is only 75 μm thick, flexible, and light-weight.We acknowledge financial support from the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom via the EPSRC Centre for Doctoral Training in Metamaterials (Grant No. EP/L015331/1). J.P.G. wishes to thank Flann Microwave Ltd (Bodmin, UK) for additional financial support of her studentshi

Direct gas-in-place measurements prove much higher production potential than expected for shale formations

Shale gas exploitation has been the game-changer in energy development of the past decade. However, the existing methods of estimating gas in place in deep formations suffer from large uncertainties. Here, we demonstrate, by using novel high-pressure experimental techniques, that the gas in place within deep shale gas reservoirs can be up to five times higher than that estimated by implementing industry standard approaches. We show that the error between our laboratory approach and the standard desorption test is higher for gases with heavier compositions, which are of strongest commercial interests. The proposed instrumentation is reliable for deep formations and, provides quick assessment of the potential for the gas in place, which could be useful for assessing hydrocarbon reservoirs, and the potential for geological carbon sequestration of a given formation

Prospectively Collected Characteristics of Adult Patients, Their Consultations and Outcomes as They Report Breathlessness When Presenting to General Practice in Australia

Introduction:Breathlessness is a subjective sensation, so understanding its impacts requires patients' reports, including prospective patient-defined breathlessness as a reason for presenting to general practitioners (GP).The aim of this study was to define the prevalence of breathlessness as a reason for GP consultations while defining the clinico-demographic factors of these patients and the characteristics and outcomes of those consultations.Methods:Using nine years of the Family Medicine Research Centre database of 100 consecutive encounters from 1,000 practices annually, the patient-defined reason for encounter 'breathlessness' was explored using prospectively collected data in people ≥18 years with clinical data coded using the International Classification for Primary Care V2. Dichotomous variables were analysed using chi square and 95% confidence intervals calculated using Kish's formula for a single stage clustered design.Results:Of all the 755,729 consultations collected over a nine year period from 1 April, 2000, 7255 included breathlessness as a reason for encounter (0.96%; 95% CI 0.93 to 0.99) most frequently attributed to chronic obstructive pulmonary disease. Only 48.3% of GPs saw someone reporting breathlessness. The proportion of consultations with breathlessness increased with age. Breathlessness trebled the likelihood that the consultation occurred in the community rather than the consulting room (p<0.0001) and increased 2.5 fold the likelihood of urgent referral to hospital (p<0.0001). Of those with breathlessness, 12% had undiagnosed breathlessness at the end of the consultation (873/7255) with higher likelihood of being younger females.Discussion:Breathlessness is a prevalent symptom in general practitioner. Such prevalence enables future research focused on understanding the temporal pattern of breathlessness and the longitudinal care offered to, and outcomes for these patients, including those who leave the consultation without a diagnosis. © 2013 Currow et al

Mutagenesis of Snu114 domain IV identifies a developmental role in meiotic splicing

<p>Snu114, a component of the U5 snRNP, plays a key role in activation of the spliceosome. It controls the action of Brr2, an RNA-stimulated ATPase/RNA helicase that disrupts U4/U6 snRNA base-pairing prior to formation of the spliceosome’s catalytic centre. Snu114 has a highly conserved domain structure that resembles that of the GTPase EF-2/EF-G in the ribosome. It has been suggested that the regulatory function of Snu114 in activation of the spliceosome is mediated by its C-terminal region, however, there has been only limited characterisation of the interactions of the C-terminal domains. We show a direct interaction between protein phosphatase PP1 and Snu114 domain ‘IVa’ and identify sequence ‘YGVQYK’ as a PP1 binding motif. Interestingly, this motif is also required for Cwc21 binding. We provide evidence for mutually exclusive interaction of Cwc21 and PP1 with Snu114 and show that the affinity of Cwc21 and PP1 for Snu114 is influenced by the different nucleotide-bound states of Snu114. Moreover, we identify a novel mutation in domain IVa that, while not affecting vegetative growth of yeast cells, causes a defect in splicing transcripts of the meiotic genes, <i>SPO22, AMA1</i> and <i>MER2</i>, thereby inhibiting an early stage of meiosis.</p

Non-palimpsested crowded Skolithos ichnofabrics in a Carboniferous tidal rhythmite: Disentangling ecological signatures from the spatio-temporal bias of outcrop

Funder: International Association of Sedimentologists; Id: http://dx.doi.org/10.13039/501100007463A heterolithic tidalite succession yielding spring–neap bundles is newly reported from a mid- Carboniferous (Serpukhovian) section of the Alston Formation of Northumberland, England. The rhythmite records deposition over an interval that can be confidently calibrated to at least 84 lunar days, and attests to a non-negligible tidal range in parts of the Northwest European Seaway in the late Mississippian. The tidalite is notable for the presence of a striking crowded Skolithos ichnofabric on both bedding planes and in vertical section. Bedding plane expressions of the ichnofabric reveal true substrates of sand piles excavated during burrow construction, in addition to an apparently remarkable equal spacing between individual burrows that is shown to be genuine through pair correlation function analysis. These characteristics show that the burrowed horizons were registered by contemporaneous ichnocoenoses, with no palimpsesting of burrows. The irregular vertical distribution of burrow horizons, despite a near-continuous semi-diurnal record of sedimentation, is suggested to be an artefact of spatial patchiness of burrowing communities in the depositional environment; imperfectly registered in a vertical profile with high-temporal, lowspatial resolution. The succession proves that burrow palimpsesting is not an inevitable ichnological conclusion of sedimentary stasis, and attests to intermittent palaeoecological fidelity of the stratigraphic record at the small spatio-temporal scales recorded a

The impact of the UK COVID-19 pandemic on patient-reported health outcomes after stroke: a retrospective sequential comparison

BACKGROUND AND PURPOSE: The COVID-19 pandemic and related social isolation measures are likely to have adverse consequences on community healthcare provision and outcome after acute illnesses treated in hospital, including stroke. We aimed to evaluate the impact of the COVID-19 pandemic on patient-reported health outcomes after hospital admission for acute stroke. METHODS: This retrospective study included adults with acute stroke admitted to the University College Hospital NHS Foundation Trust Hyperacute Stroke Unit. We included two separate cohorts of consecutively enrolled patients from the same geographical population at two time points: 16th March-16th May 2018 (pre-COVID-19 pandemic); and 16th March-16th May 2020 (during the COVID-19 pandemic). Patients in both cohorts completed the validated Patient Reported Outcomes Measurement Information System-29 (PROMIS-29 version 2.0) at 30 days after stroke. RESULTS: We included 205 patients who were alive at 30 days (106 admitted before and 99 admitted during the COVID-19 pandemic), of whom 201/205 (98%) provided patient-reported health outcomes. After adjustment for confounding factors, admission with acute stroke during the COVID-19 pandemic was independently associated with increased anxiety (β = 28.0, p < 0.001), fatigue (β = 9.3, p < 0.001), depression (β = 4.5, p = 0.002), sleep disturbance (β = 2.3, p = 0.018), pain interference (β = 10.8, p < 0.001); and reduced physical function (β = 5.2, p < 0.001) and participation in social roles and activities (β = 6.9, p < 0.001). CONCLUSION: Compared with the pre-pandemic cohort, patients admitted with acute stroke during the first wave of the COVID-19 pandemic reported poorer health outcomes at 30 day follow-up in all domains. Stroke service planning for any future pandemic should include measures to mitigate this major adverse impact on patient health

Dark Mode Excitation in Three-Dimensional Interlaced Metallic Meshes

This is the final version. Available on open access from the American Chemical Society via the DOI in this recordData Availability. The data that support the findings of this study are available from the corresponding author upon reasonable request.Interlaced metallic meshes form a class of three-dimensional metamaterials that exhibit nondispersive, broadband modes at low frequencies, without the low frequency cutoff typical of generic wire grid geometries. However, the experimental observation of these modes has remained an open challenge, both due to the difficulties in fabricating such complex structures and also because the broadband mode is longitudinal and does not couple to free-space radiation (dark mode). Here we report the first experimental observation of the low frequency modes in a block of interlaced meshes fabricated through 3D printing. We demonstrate how the addition of monopole antennas to opposing faces of one of the meshes enables coupling of a plane wave to the low frequency “dark mode” and use this to obtain the dispersion of the mode. In addition, we utilize orthogonal antennas on opposite faces to achieve polarization rotation as well as phase shifting of radiation passing through the structure. Our work paves the way toward further experimental study into interlaced meshes and other complex 3D metamaterials.Royal Academy of Engineering (RAE)Engineering and Physical Sciences Research Council (EPSRC